3,4-Dimethoxycinnamic acid

CAS No. 2316-26-9

3,4-Dimethoxycinnamic acid( O-Methylferulic acid )

Catalog No. M19332 CAS No. 2316-26-9

3, 4-Dimethoxycinnamic acid, previously identified in plasma after coffee consumption, was rapidly absorbed in the free form most likely by passive diffusion in the upper gastrointestinal tract.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    3,4-Dimethoxycinnamic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    3, 4-Dimethoxycinnamic acid, previously identified in plasma after coffee consumption, was rapidly absorbed in the free form most likely by passive diffusion in the upper gastrointestinal tract.
  • Description
    3, 4-Dimethoxycinnamic acid, previously identified in plasma after coffee consumption, was rapidly absorbed in the free form most likely by passive diffusion in the upper gastrointestinal tract.
  • In Vitro
    3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 μM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells. 3,4-Dimethoxycinnamic acid (25, 50 and 100 μM) inhibits the expression levels of Nox4 and p22phox in L-02 cells. 3,4-Dimethoxycinnamic acid (25, 50 and 100 μM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells.3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner.
  • In Vivo
    ——
  • Synonyms
    O-Methylferulic acid
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2316-26-9
  • Formula Weight
    208.21
  • Molecular Formula
    C11H12O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (240.14 mM)
  • SMILES
    COC1=C(C=C(C=C1)/C=C/C(=O)O)OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Farrell TL,et al.Absorption of dimethoxycinnamic acid derivatives in vitro and pharmacokinetic profile in human plasma following coffee consumption. 2012 Sep;56(9):1413-23.
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